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. 2018 Feb 21;8:3390. doi: 10.1038/s41598-018-21630-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Breadth of T cell response. (A) Response breadth by number of positive ELISpot pools per group at the peak post vaccination: 14–28 days post-ChAd63 ME-TRAP and 7–28 days post-MVA ME-TRAP. Median plus interquartile range displayed to a maximum of 7 pools: TRAP T9/96 (TT) pool 1–6 and multiple epitope pool. Response breadth to ChAd63 ME-TRAP and MVA ME-TRAP by Mann-Whitney test at vaccination 2 and 3, p = 0.0002 and p < 0.0001 respectively, as shown in 2B and 2 C. ***p < 0.001, ****p < 0.0001. 3 C) Distribution of positive responses toward each ELISpot pool, as a proportion of overall positive responses. Groups combined to assess multiple prime (group 1 AAA_M, group 2 A_A_M, group 3 AAM), multiple boost (group 4 A_M_M_M), alternating vectors (group 5 AMA_M, group 6 AMAM, group 7 A_M_A_M) and single prime boost (group 5 + 6 AM, group 4 + 7 A_M).