Table 1.
Baseline Characteristics of the CoreValve Extreme Risk Cohort
| Iliofemoral (N=454) | Non-Iliofemoral (N=141) | |
|---|---|---|
| Clinical Characteristics | ||
| Age (years) | 83.5 ± 8.6 | 81.3 ± 7.5 |
| Male | 47.8% (217/454) | 46.8% (66/141) |
| STS Risk Score | 10.4 ± 5.6 | 10.7 ± 5.8 |
| NYHA Class III/IV | 91.8% (417/454) | 92.2% (130/141) |
| Diabetes | 40.5% (184/454) | 34.0% (48/141) |
| Previous CABG | 39.4% (179/454) | 41.1% (58/141) |
| Prior Myocardial Infarction | 31.3% (142/454) | 33.3% (47/141) |
| Prior Cerebrovascular Accident | 19.2% (87/454) | 19.3% (27/141) |
| Peripheral Arterial Disease | 35.9% (162/454) | 60.3% (85/141) |
| Prior Atrial Fibrillation/Flutter | 47.6% (215/454) | 48.6% (68/141) |
| Chronic Lung Disease requiring Home Oxygen | 29.3% (133/454) | 42.6% (60/141) |
| Chronic Kidney Disease | 13.6% (61/454) | 14.3% (20/141) |
| Hostile Chest | 21.0% (95/454) | 19.1% (27/141) |
| Wheelchair Bound | 15.6% (71/454) | 9.9% (14/141) |
| Left Ventricular Ejection Fraction (%) | 54.2% ± 14.4 | 54.9% ± 14.2 |
| Mean AV gradient (mmHg) | 47.4 ± 14.6 | 49.7 ± 17.1 |
|
| ||
| Baseline Health Status | ||
| KCCQ Overall Summary | 37.9 ± 22.1 | 42.5 ± 22.3 |
| KCCQ Physical Limitations | 35.3 ± 24.8 | 41.4 ± 24.7 |
| KCCQ Quality of Life | 36.3 ± 24.6 | 38.9 ± 22.5 |
| KCCQ Total Symptoms | 48.2 ± 24.1 | 51.9 ± 24.7 |
| KCCQ Social Limitations | 30.4 ± 28.5 | 38.2 ± 30.1 |
| SF-12 Physical Summary | 28.5 ± 8.3 | 27.9 ± 8.0 |
| SF-12 Mental Summary | 45.8 ± 12.3 | 47.6 ± 12.0 |
| EQ-5D Utilities | 0.65 ± 0.23 | 0.67 ± 0.23 |
Abbreviations: STS – Society of Thoracic Surgeons; NYHA – New York Heart Association; CABG – coronary artery bypass grafting; AV – aortic valve; KCCQ – Kansas City Cardiomyopathy Questionnaire; SF – Short Form; EQ – EuroQoL