Fig. 1.

Histone Acetylation and Parkinson’s Disease Progression.

Histone acetylation (AcH3-Lys9) was quantified in the Substantia Nigra pars compacta (SNpc) of each control, each early, and each late PD case relative to β-Actin using Western blot analysis. (A) Bar graph illustrating level of AcH3-Lys9 observed in each group of cases. (B) Representative blot of data presented in (A). (C) Graphical representation of correlation between Braak Stage of human cases and AcH3-Lys9 observed in the SNpc of that case. N = 8-12 per group (see supplementary Table 1). Statistical significance indicated with asterisks: *p < .05. Abbreviations: ePD, early Parkinson’s disease; lPD, late Parkinson’s disease.