Table 3. Univariate and multivariate analysis of recurrence-related factors in CRC patients.

Variable	Univariate		Multivariate
	Hazard ratio (HR, 95%CI)	P	HR (95%CI)	P
Age	0.998 (0.972–1.024)	0.86	0.997 (0.966–1.028)	0.840
Gender
Male	2.654 (1.273–5.534)	0.007	3.605 (1.552–8.374)	0.003
Female	1		1
TNM stage
Early stage (stage I + stage II)	0.481 (0.241 to 0.959)	0.038	0.384 (0.173–0.852)	0.019
Late stage (stage III + stage IV)	1		1
Perineural invasion
YES	1		1
NO	0.824 (0.408–1.664)	0.590	1.180 (0.524–2.660)	0.689
Lymphatic invasion
YES	1		1
NO	0.480 (0.237 to 0.973)	0.042	0.819 (0.292–2.300)	0.705
Venous invasion
YES	1		1
NO	0.564 (0.275–1.158)	0.119	0.888 (0.317–2.488)	0.821
ABCB4 expression
High	1		1
Low	2.142 (1.032–4.449)	0.041	2.743 (1.291–5.827)	0.01