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. 2018 Jan 11;2018:7239123. doi: 10.1155/2018/7239123

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Copyright © 2018 Rodrigo L. Castillo et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Quercetin protects against the decrease in cardiac antioxidant defenses induced by high-cholesterol diet. Antioxidant defenses (a) GSH/GSSG ratio, (b) nuclear translocation of Nrf2, (c) HO-1 expression, and activities of (d) SOD, (e) catalase, and (f) glutathione peroxidase in the heart from rats fed for 4 weeks with control diet (C), control diet containing 0.5% quercetin diet (CQ), high-cholesterol diet (HC), and high-cholesterol diet containing 0.5% quercetin (HCQ). Values are expressed as mean ± SEM. N = 6–8 rats/group. Two-way ANOVA test and Bonferroni posttest. Statistical differences: ^∗ p < 0.05, ^∗∗ p < 0.01, ^∗∗∗ p < 0.001, and ^∗∗∗∗ p < 0.0001.