Table 1.

Frequency of occurrence of substitutions at amino acid positions 70 and 91 of the nucleocapsid (core) protein of HCV genotypes 1a, 1b, and 3a in different population groups (in %).

HCV genotype	Substitutions	Geographical variation in % of sequences variants in HCV of different genotypes
		Russia	Europe	Asia	USA	Total
1a	nn samples	n = 29	n = 149	n = 27	n = 1087	n = 1292
	Q70	3.4	0.7	0	1.7	1.5
	H70	0	0	0	0.1	0.1
	M91	0	0	0	0	0
	Both∗	0	0	0	0	0
	None∗∗	96.6	99.3	100	98.2	98.4
1b	nn samples	n = 189	n = 316	n = 224	n = 218	n = 947
	Q70	27.0	17.7	31.3	59.6	32.4
	H70	4.2	0.3	2.7	3.2	2.3
	M91	80.4	85.8	43.8	86.2	74.9
	Both∗	27.5	15.5	16.1	54.6	27.0
	None∗∗	15.9	11.7	38.4	5.5	17.4
3a	nn samples	n = 171	n = 28	n = 123	n = 38	n = 360
	Q70	2.9	7.1	9.8	0	5.3
	H70	0	0	0	0	0
	M91	0.6	0	0	0	0.3
	Both∗	0	0	0	0	0
	None∗∗	96.5	92.9	90.2	100	94.4

^∗Substitutions in both aa 70 and 91; ^∗∗no substitutions.