Table 2.
Occurrence of substitutions in amino acid positions 70 and 91 of the nucleocapsid (core) protein of HCV 1b in the samples collected from the general population of the Russian Federation during the routine blood tests.
| Number of cohort | Federal District of Russia | City | Date of collection of samples | Number of HCV 1b sequences | Mutations found in aa position 70, n (%) | Mutations found in aa position 91, n (%) | Mutations found in aa positions 70 and 91, n (%) | Without mutations in aa positions 70 and 91, n (%) |
|---|---|---|---|---|---|---|---|---|
| 1 | Central | Moscow | 2008 | 5 | 1 (20.0) | 4 (80.0) | 1 (20.0) | 1 (20.0) |
| 2009 | 6 | 1 (16.7) | 5 (83.3) | 0 (0) | 0 (0) | |||
| 2011 | 17 | 10 (58.9) | 15 (88.2) | 9 (53.0) | 1 (5.9) | |||
| 2014 | 21 | 7 (33.3) | 16 (76.2) | 6 (28.6) | 4 (19.0) | |||
| 2008–2014 | 49 | 19 (38.7) | 40 (81.6) | 17 (34.7) | 7 (14.2) | |||
| 2014 | 45∗ | 19 (42.2) | 35 (77.7) | 16 (35.6) | 7 (15.6) | |||
| 2008–2014 | 94∗∗ | 38 (40.4) | 75 (79.8) | 33 (35.1) | 14 (14.9) | |||
| 2 | Northwest | Saint Petersburg | Before 2001 | 18 | 4 (22.2) | 15 (83.3) | 3 (16.7) | 2 (11.1) |
| 3 | Southern | Rostov-on-Don | 2008 | 8 | 0 (0) | 8 (100) | 0 (0) | 0 (0) |
| 4 | Ural | Yekaterinburg | 2008 | 3 | 1 (33.3) | 3 (100) | 1 (33.3) | 0 (0) |
| 5 | Siberian | Novosibirsk | Before 2005 | 29 | 6 (20.8) | 22 (75.9) | 6 (20.7) | 7 (23.8) |
| 6 | Kyzyl | 2008 | 6 | 1 (16.7) | 4 (66.7) | 0 (0) | 1 (16.7) | |
| 7 | Far Eastern | Yakutsk | 2008 | 7 | 1 (14.3) | 6 (85.7) | 1 (14.3) | 1 (14.3) |
| 8 | Khabarovsk | 2009 | 24 | 8 (33.3) | 19 (79.2) | 8 (33.3) | 5 (20.8) |
∗Intravenous drug users (IDUs); ∗∗all samples including IDUs.