Video 2. Retinal Architecture and the Melanopsin-Mediated Persistent Pupillary Constriction Response.
The normal pupillary responses to both red and blue light stimulation, with the latter characterized by persistence of the constriction phase of the reflex and mediated by the melanopsin-containing cells of the retina that project to the rostral midbrain. Furthermore, we highlight the highly conspicuous diminishment of the blue light stimulation–induced melanopsin-mediated protracted pupillary constriction phase of the reflex in multiple sclerosis–affected eyes associated with a history of acute optic neuritis and/or a significant reduction in the retinal thickness of the ganglion cell layer and inner plexiform layer. This award-winning research was presented at the European Committee for the Treatment and Research of Multiple Sclerosis (Drs Meltzer and Sguigna).