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. 2018 Jan 29;7(1):e1008. doi: 10.1002/cti2.1008

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© 2018 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australasian Society for Immunology Inc.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Regulatory and IL‐17⁺ T cells are increased throughout normal and abortive gestation. (a) Number of implanted foetuses counted at day 12.5 of pregnancy in uteri from DBA/2J‐ or BALB/c‐mated CBA/J females, n = 16 per group. (b) Rate of foetal resorption calculated at day 12.5 of pregnancy in uteri from DBA/2J‐ or BALB/c‐mated CBA/J females, n = 16 per group. (c) RT‐qPCR analysis of Foxp3 mRNA expression in uterine tissue of pregnant DBA/2J‐ or BALB/c‐mated CBA/J females on days of pregnancy 1.5, 4.5, 6.5, 12.5, n = 6–12. (d) RT‐qPCR analysis of Il10 mRNA expression in uterine tissue of pregnant DBA/2J‐ or BALB/c‐mated CBA/J females on days of pregnancy 1.5, 4.5, 6.5, 12.5, n = 6–12. (e) Percentage of Treg (CD4⁺ Foxp3⁺ cells) amongst CD3⁺ CD4⁺ cells in uteri from pregnant DBA/2J‐ or BALB/c‐mated CBA/J females on days of pregnancy 1.5, 4.5, 6.5, 12.5 and from nonpregnant BALB/c females, n = 6–12 per group. (f) Absolute Treg cell numbers in uteri from pregnant DBA/2J‐ or BALB/c‐mated CBA/J females on days of pregnancy 1.5, 4.5, 6.5, 12.5 and from nonpregnant BALB/c females, n = 6–12 per group. (g) Percentage of IL‐17A‐producing T cells (CD3⁺ IL‐17A⁺ cells amongst CD45⁺ cells) in uteri from pregnant DBA/2J‐ or BALB/c‐mated CBA/J females on days of pregnancy 1.5, 4.5, 6.5, 12.5 and from nonpregnant BALB/c females at oestrus phase, n = 6–12 per group. (h) Absolute cell numbers of IL‐17A‐producing T cells (CD3⁺ IL‐17a⁺ cells amongst CD45⁺ cells) in uteri from pregnant DBA/2J‐ or BALB/c‐mated CBA/J females on days of pregnancy 1.5, 4.5, 6.5, 12.5 and from nonpregnant BALB/c females, n = 5–12 per group. (i) Correlation between the foetal resorption rate and IL‐17A‐producing cells proportion (IL‐17A⁺ cells amongst CD45⁺) in uteri of pregnant DBA/2J‐ or BALB/c‐mated CBA/J females on day 12.5 of pregnancy, n = 14. Results are shown as mean ± SEM and are representative of at least three experiments. Mann–Whitney and Kruskal–Wallis tests were used. *P < 0.05, **P < 0.01, ***P < 0.001. ▲ Nonpregnant, ○ CBA/J x BALB/c, ● CBA/J x DBA/2.