Table 1.
Comparison of tumor types and 12-CK gene expression signature (GES) scores by RSI-low (more radiosensitive, RSI≤0.3745) and RSI-high (less radiosensitive, RSI>0.3745) groups. Tumor types are sorted from highest to lowest 12-CK GES (most to least immune-active) within the RSI-low group. Tumor types with <10 samples in either RSI group were not compared.
| Tumor site and histology | RSI GES ≤ 0.3745 | RSI GES > 0.3745 | p | ||
|---|---|---|---|---|---|
|
| |||||
| N (%) | Median 12-CK GES (IQR) | N (%) | Median 12-CK GES (IQR) | ||
| Esophageal SCCa | 1 (16.7) | 1.959 (1.959, 1.959) | 5 (83.3) | −0.492 (−0.696, 0.217) | - |
| Breast Medullary Carcinoma | 7 (87.5) | 1.656 (1.517, 1.963) | 1 (12.5) | 1.328 (1.328, 1.328) | - |
| Thyroid Papillary Carcinoma | 3 (10.7) | 1.478 (1.336, 1.779) | 25 (89.3) | −0.860 (−1.266, −0.127) | - |
| Vulva squamous | 1 (25.0) | 1.453 (1.453, 1.453) | 3 (75.0) | 0.759 (0.556, 0.895) | - |
| Lung Large Cell Carcinoma | 28 (66.7) | 1.394 (1.014, 1.605) | 14 (33.3) | 0.657 (−0.293, 1.352) | 0.017 |
| Desmoplastic Melanoma | 1 (20.0) | 1.370 (1.370, 1.370) | 4 (80.0) | −0.378 (−0.674, −0.051) | - |
| Cervix SCCa | 22 (68.8) | 1.215 (0.854, 1.475) | 10 (31.2) | 0.136 (−0.136, 0.464) | - |
| Lung Small Cell Carcinoma | 11 (31.4) | 1.129 (0.690, 1.428) | 24 (68.6) | 0.017 (−0.490, 0.576) | 0.002 |
| Pancreas Adenosquamous | 3 (60.0) | 1.059 (0.292, 1.362) | 2 (40.0) | −1.067 (−1.256, −0.877) | - |
| Oropharynx SCCa | 9 (90.0) | 1.051 (0.919, 1.612) | 1 (10.0) | 0.059 (0.059, 0.059) | - |
| Anorectal SCCa | 7 (35.0) | 1.024 (0.212, 1.274) | 13 (65.0) | 0.454 (−0.614, 0.758) | - |
| Lung Adenocarcinoma | 584 (50.1) | 1.005 (0.627, 1.358) | 581 (49.9) | 0.279 (−0.187, 0.716) | <0.001 |
| Cutaneous Melanoma | 25 (21.7) | 0.983 (0.584, 1.326) | 90 (78.3) | −0.030 (−0.611, 0.641) | <0.001 |
| Non-Oropharynx Head and Neck SCCa | 43 (45.3) | 0.939 (0.546, 1.383) | 52 (54.7) | −0.036 (−0.388, 0.548) | <0.001 |
| Lung SCCa | 311 (53.4) | 0.930 (0.575, 1.272) | 271 (46.6) | 0.305 (−0.161, 0.716) | <0.001 |
| Sarcoma | 23 (22.5) | 0.922 (0.510, 1.523) | 79 (77.5) | −0.274 (−0.917, 0.596) | <0.001 |
| Cutaneous BCCa and SCCa | 11 (35.5) | 0.919 (0.423, 1.503) | 20 (64.5) | −0.228 (−0.731, 0.009) | <0.001 |
| Ovary Dysgerminoma | 1 (50.0) | 0.916 (0.916, 0.916) | 1 (50.0) | 0.815 (0.815, 0.815) | - |
| Endometrial SCCa | 7 (58.3) | 0.833 (0.201, 1.070) | 5 (41.7) | 0.121 (0.034, 0.161) | - |
| Small Intestine Adenocarcinoma | 7 (87.5) | 0.831 (0.588, 0.913) | 1 (12.5) | −0.695 (−0.695, −0.695) | - |
| Lung Mesothelioma | 2 (16.7) | 0.828 (0.496, 1.160) | 10 (83.3) | 0.146 (−0.111, 0.608) | - |
| Lung Bronchoalveolar Carcinoma | 45 (44.1) | 0.803 (0.428, 1.130) | 57 (55.9) | 0.244 (−0.141, 0.497) | <0.001 |
| Stomach Signet ring | 3 (33.3) | 0.801 (0.451, 1.177) | 6 (66.7) | 0.210 (0.103, 0.267) | - |
| Other | 143 (32.4) | 0.796 (0.090, 1.271) | 298 (67.6) | −0.345 (−1.086, 0.291) | <0.001 |
| Lung Neuroendocrine Carcinoma | 22 (34.9) | 0.787 (0.444, 1.103) | 41 (65.1) | −0.838 (−1.884, 0.074) | <0.001 |
| Bladder SCCa | 5 (55.6) | 0.727 (−0.104, 0.916) | 4 (44.4) | 0.339 (−0.006, 0.507) | - |
| Bladder TCC | 69 (35.8) | 0.540 (−0.261, 1.266) | 124 (64.2) | −0.128 (−0.775, 0.526) | <0.001 |
| Rectal Adenocarcinoma | 37 (32.7) | 0.531 (−0.324, 0.810) | 76 (67.3) | −0.063 (−0.753, 0.306) | <0.001 |
| Large Bowel Adenocarcinoma | 600 (46.0) | 0.449 (−0.100, 0.972) | 704 (54.0) | −0.291 (−0.811, 0.184) | <0.001 |
| Pancreas Adenocarcinoma | 66 (23.7) | 0.424 (−0.086, 0.884) | 212 (76.3) | −0.092 (−0.556, 0.328) | <0.001 |
| Stomach Adenocarcinoma | 25 (47.2) | 0.348 (−0.227, 0.816) | 28 (52.8) | 0.048 (−0.508, 0.551) | 0.192 |
| Breast IDC | 1147 (46.1) | 0.333 (−0.335, 1.076) | 1340 (53.9) | 0.111 (−0.491, 0.626) | <0.001 |
| Kidney RCC | 291 (40.6) | 0.317 (−0.125, 0.798) | 425 (59.4) | −0.321 (−0.833, 0.267) | <0.001 |
| Liver HCC | 41 (85.4) | 0.161 (−0.512, 0.416) | 7 (14.6) | −0.842 (−1.289, −0.527) | - |
| Esophageal Adenocarcinoma | 28 (52.8) | 0.145 (−0.422, 0.682) | 25 (47.2) | 0.090 (−0.167, 0.506) | 0.951 |
| Stomach GIST | 7 (22.6) | 0.119 (−0.253, 0.870) | 24 (77.4) | −0.452 (−1.235, 0.047) | - |
| Endometrial Carcinosarcoma | 4 (14.8) | 0.096 (−0.217, 0.524) | 23 (85.2) | −1.145 (−1.449, −0.754) | - |
| Ovary Adenocarcinoma | 108 (42.7) | 0.070 (−0.646, 0.599) | 145 (57.3) | −0.845 (−1.565, −0.164) | <0.001 |
| Ampulla Of Vater Adenocarcinoma | 10 (62.5) | 0.065 (−0.142, 0.220) | 6 (37.5) | −0.715 (−1.297, 0.032) | - |
| Bladder Adenocarcinoma | 3 (42.9) | 0.054 (−0.778, 0.966) | 4 (57.1) | −1.029 (−1.275, −0.458) | - |
| Kidney Urothelial Carcinoma | 23 (67.6) | −1.574 (−1.792, −0.851) | 11 (32.4) | −1.134 (−2.411, −0.369) | 0.913 |
| Brain Glioma | 3 (1.7) | −1.056 (−1.244, −0.548) | 171 (98.3) | −1.355 (−1.827, −0.901) | - |
| Pancreas Neuroendocrine Carcinoma | 6 (11.3) | −0.692 (−0.846, −0.564) | 47 (88.7) | −0.999 (−1.585, −0.695) | - |
| Endometrial Sarcoma | 4 (28.6) | −0.601 (−0.859, −0.056) | 10 (71.4) | −1.168 (−1.685, −0.517) | - |
| Lung Carcinoid Tumor | 7 (8.9) | −0.581 (−1.233, 0.279) | 72 (91.1) | −1.790 (−2.105, −1.218) | - |
| Large Bowel Neuroendocrine Carcinoma | 7 (46.7) | −0.569 (−1.284, −0.277) | 8 (53.3) | −1.220 (−1.404, −0.984) | - |
| Endometrial Adenosquamous | 7 (23.3) | −0.252 (−0.789, 0.532) | 23 (76.7) | −0.590 (−1.355, −0.289) | - |
| Prostate Adenocarcinoma | 73 (39.2) | −0.226 (−1.007, 0.158) | 113 (60.8) | −0.661 (−1.065, −0.282) | <0.001 |
| Breast Mucinous/Tubular/Papillary Carcinoma | 35 (42.7) | −0.173 (−0.669, 0.310) | 47 (57.3) | −0.160 (−0.772, 0.450) | 0.723 |
| Endometrial Adenocarcinoma | 180 (32.5) | −0.116 (−0.760, 0.496) | 374 (67.5) | −0.756 (−1.196, −0.197) | <0.001 |
| Cervix Adenocarcinoma | 10 (58.8) | −0.114 (−0.436, 0.517) | 7 (41.2) | −0.873 (−1.109, −0.742) | - |
| Large Bowel Signet ring | 3 (27.3) | −0.045 (−0.169, 0.197) | 8 (72.7) | 0.220 (−0.095, 0.522) | - |
| Breast ILC | 172 (40.3) | −0.020 (−0.605, 0.540) | 255 (59.7) | −0.025 (−0.468, 0.424) | 0.547 |
| Ovary Granulosa Cell Carcinoma | 0 (0.0) | NA | 10 (100.0) | −1.603 (−1.911, −1.076) | - |