Table 2.
Age-adjusted risk of distant metastasis free survival in the Erasmus breast cancer cohort compared using Cox multivariate modeling with clinicopathologic and treatment variables and a) RSI gene expression signature (GES) alone, b) 12-CK GES alone, and (c) RSI and 12-CK GES combined.
| Variable | HR | CI (low) | CI (high) | P | |
|---|---|---|---|---|---|
| RSI | Age (years) | 0.99 | 0.97 | 1 | 0.11 |
| RSI-S (ref: RSI-R) | 0.58 | 0.34 | 1 | 0.05 | |
|
| |||||
| 12-CK | Age (years) | 0.98 | 0.96 | 1.00 | 0.04 |
| 12-CK- high (ref: 12-CK- low) | 0.61 | 0.39 | 0.96 | 0.03 | |
|
| |||||
| RSI and 12-CK | Age (years) | 0.98 | 0.97 | 1.00 | 0.05 |
| RSI-S (ref: RSI-R) | 0.63 | 0.36 | 1.09 | 0.10 | |
| 12-CK- high (ref: 12-CK- low) | 0.66 | 0.41 | 1.04 | 0.07 | |