. 2017 Mar 21;23(3):789–790. doi: 10.1038/mp.2017.70

Table 4.

Associations between polygenic profile scores of health-related traits created from GWAS consortia summary data, and the UK Biobank tiredness phenotype controlling for age, sex, assessment centre, genotyping batch and array, and 10 principal components for population structure

Trait category	Trait	Threshold	β	P-value
Physical health	Blood pressure: diastolic	0.1	−0.0028	0.3619
	Blood pressure: systolic	0.1	−0.0025	0.4077
	BMI	1	0.0280	4.90 × 10⁻²⁰^a
	Cholesterol: HDL	0.5	−0.0163	8.49 × 10⁻⁸^a
	Cholesterol: LDL	0.5	0.0081	0.0077 ^a
	Coronary artery disease	0.5	0.0084	0.0061
	C-reactive protein	1	0.0130	2.10 × 10⁻⁵^a
	Forced expiratory volume 1s	0.01	−0.0059	0.0529
	Longevity	0.05	−0.0067	0.0297
	HbA1c	1	0.0090	0.0033 ^a
	Height	1	−0.0077	0.0154
	Obesity	1	0.0236	1.20 × 10⁻¹⁴^a
	Rheumatoid arthritis	0.1	−0.0016	0.5926
	Smoking status	0.5	0.0086	0.0071
	Triglycerides	0.5	0.0209	1.06 × 10⁻¹¹^a
	Type 2 diabetes	1	0.0120	0.0002^a,^b
	Waist–hip ratio	1	0.0258	7.85 × 10⁻¹⁷^a
Mental health	ADHD	1	0.0042	0.1647
	Alzheimer’s disease	0.05	−0.0052	0.0889
	Anorexia nervosa	0.5	0.0048	0.1169
	Autism	1	−0.0018	0.5593
	Bipolar disorder	0.01	0.0081	0.0076 ^c
	Childhood cognitive ability	0.1	−0.0112	0.0002 ^a
	Major depressive disorder	0.1	0.0185	2.25 × 10⁻⁹^c
	Neuroticism	1	0.0183	2.00 × 10⁻⁹^c
	Schizophrenia	1	0.0283	2.31 × 10⁻¹⁹^a,^c

Abbreviations: ADHD, attention deficit hyperactive disorder; BMI, body mass index; GWAS, genome-wide association study; HbA1c, hemoglobin A1c; HDL, high-density lipoproteins; LDL, low-density lipoproteins.

False discovery rate-corrected statistically significant values (P=0.0255) are shown in bold. The associations between the polygenic profile scores with the largest effect size (threshold) and tiredness are presented. Threshold is the P-value threshold with the largest effect size.

^aResults remain significant after controlling for neuroticism scores.

^bResults remain significant after excluding individuals with type 2 diabetes (β=0.0105, P=0.00076).

^cResults remain significant after controlling for self-rated health.