Table 4. Associations between polygenic profile scores of health-related traits created from GWAS consortia summary data, and the UK Biobank tiredness phenotype controlling for age, sex, assessment centre, genotyping batch, and array and 10 principal components for population structure.

Trait category	Trait	Threshold	β	P
Physical health	Blood pressure: diastolic	0.1	−0.0028	0.3619
	Blood pressure: systolic	0.1	−0.0025	0.4077
	BMI	1	0.0280	4.90 × 10−20a
	Cholesterol: HDL	0.5	−0.0163	8.49 × 10−8a
	Cholesterol: LDL	0.5	0.0081	0.0077a
	Coronary artery disease	0.5	0.0084	0.0061
	C-reactive protein	1	0.0130	2.10 × 10−5a
	Forced expiratory volume 1 s	0.01	−0.0059	0.0529
	Longevity	0.05	−0.0067	0.0297
	HbA1c	1	0.0090	0.0033a
	Height	1	−0.0077	0.0154
	Obesity	1	0.0236	1.20 × 10−14a
	Rheumatoid arthritis	0.1	−0.0016	0.5926
	Smoking status	0.5	0.0086	0.0071
	Triglycerides	0.5	0.0209	1.06 × 10−11a
	Type 2 diabetes	1	0.0120	0.0002a,b
	Waist–hip ratio	1	0.0258	7.85 × 10−17a
Mental health	ADHD	1	0.0042	0.1647
	Alzheimer’s disease	0.05	−0.0052	0.0889
	Anorexia nervosa	0.5	0.0048	0.1169
	Autism	1	−0.0018	0.5593
	Bipolar disorder	0.01	0.0081	0.0076c
	Childhood cognitive ability	0.1	−0.0112	0.0002a
	Major depressive disorder	1	0.0185	2.25 × 10−9c
	Neuroticism	0.1	0.0183	2.00 × 10−9c
	Schizophrenia	1	0.0283	2.31 × 10−19a,c

Abbreviations: ADHD, attention deficit hyperactivity disorder; BMI, body mass index; FDR, false discovery rate; GWAS, genome-wide association study; HDL, high-density lipoprotein; LDL, low-density lipoprotein.

FDR-corrected statistically significant values (P=0.0255) are shown in bold. The associations between the polygenic profile scores with the largest effect size (threshold) and tiredness are presented. Threshold is the P-value threshold with the largest effect size.

^aResults remain significant after controlling for neuroticism scores.

^bResults remain significant after excluding individuals with type 2 diabetes (β=0.0105, P=0.00076).

^cResults remain significant after controlling for self-rated health.