Fig. 4.

Analysis of TSS shape in D. melanogaster 3rd instar larvae. Heatmap describing enrichment of 16 motifs associated with D. melanogaster promoters (columns) in each TSS (rows) with more than 100 start-seq reads mapping to its dominant peak. Row clustering dendrogram partitions genes into three groups (outlined in red, described at right). b Boxplots describing distributions of Pause Index (left) and Shape Index (right) values in TSSs belonging to Cluster 1 (red), Cluster 2 (Blue), or Clutser 3 (Green). P-values generated by Kolmogorov-Smirnov Test. c ATAC-seq signal (left) and predicted nucleosome occupancy (right) in a 1 kb window around obsTSSs belonging to Cluster 1, 2, or 3