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. 2018 Feb 21;15:52. doi: 10.1186/s12974-018-1087-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — MA-induced changes in dynorphin level, prodynorphin mRNA, and substance P mRNA expression. Changes in dynorphin level (a), prodynorphin (b), and substance P (c) mRNA expression in the dorsal striatum of wild-type mice. Sal = saline, MA = methamphetamine 35 mg/kg, i.p. Each value is the mean ± SEM of six animals (one-way ANOVA followed by Fisher’s LSD pairwise comparisons)