Fig. 7.

Role of κ-opioid and neurokinin 1 receptors in GRe-mediated anti-apoptotic potentials. Effects of neurokinin 1 receptor antagonist L-733,060 on κ-opioid receptor antagonist Nor-B-mediated pharmacological activity in response to effects of GRe against the changes in Bax (a), cleaved caspase-3 (b), and Bcl-2 expression (c) induced by MA in the striatum of DYN KO mice. Sal = saline, MA = methamphetamine 35 mg/kg, i.p., GRe = ginsenoside Re 20 mg/kg, i.p., Nor-B = Nor-binaltorphimine 3 or 6 mg/kg, i.p., L733 = L-733,060 5 or 10 mg/kg, i.p., WT = wild type, DYN KO = prodynorphin knockout. Each value is the mean ± SEM of six animals (one-way ANOVA followed by Fisher’s LSD pairwise comparisons)