Table 3.

Change from baseline in mTSS at week 24^a in select subgroups

	Patients with mTSS results N		Change from baseline to week 24 LSM (SE)		Interaction P value
	Placebo	Baricitinib 4 mg	Placebo	Baricitinib 4 mg
Tobacco use
Smoker	126	142	1.06 (0.26)	0.59 (0.25)	0.942
Non-smoker	518	525	0.72 (0.08)	0.24 (0.08)
Weight (kg)
<60	200	180	1.11 (0.17)	0.45 (0.18)	0.566
≥60  to <100	391	432	0.67 (0.11)	0.27 (0.10)
≥100	53	56	0.43 (0.14)	0.10 (0.14)

^aData included up to rescue using linear extrapolation.

LSM, least squares mean; mTSS, modified Total Sharp Score; N, number of modified intent-to-treat patients in the specified treatment subgroup.