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. 2018 Feb 21;15:53. doi: 10.1186/s12974-018-1093-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Nrg-1 therapy significantly attenuates antibody deposition in the injured spinal cord tissue at subacute stage of SCI. a–d Immunohistochemical assessment of injured spinal cord tissue for IgM and IgG deposition was performed at the epicenter and perilesional areas at subacute (7 days) and chronic (42 days) stages of SCI. a, c Analysis of IgM immunointensity showed a significantly lower IgM deposition in Nrg-1-treated animals compared to vehicle-treated group at 7-day post-SCI. This decrease was significant at the epicenter, 1 mm caudal and 1 and 2 mm rostral to the injury site. No significant difference in IgM deposition was detected at 42-day time-point. b, d Comparison of IgG immunointensity between the vehicle- and Nrg-1-treated animals revealed a significant decrease in IgG deposition only at 1 mm rostral to the epicenter at 7-day post-injury. No significant difference was detected in IgG deposition between the vehicle- and Nrg-1-treated groups at 42-day time-point. e, f Representative images are provided at the epicenter and 1 mm rostral and caudal to the lesion center (N = 4/group/time-point, *p < 0.05, **p < 0.01, ***p < 0.001, two-way ANOVA followed by Holm-Sidak post hoc test)