Table 3.
Addition of prognostic value of gene expression signatures on top of Ki67 or IHC and vice versa for all, ER+/LN−, ER+/LN+, ER− patients based on likelihood ratio (LR-χ2) test in cohort 2
| Added prognostic value of gene expression signatures on top of Ki67/IHC and vice versa, cohort 2 | ||||||||
|---|---|---|---|---|---|---|---|---|
| All (n = 209, events = 66) |
ER+/LN− (n = 115, events = 25) |
ER+/LN+ (n = 65, events = 34) |
ER− (n = 24, events = 7) |
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| Model | LR-χ2 | P | LR-χ2 | P | LR-χ2 | P | LR-χ2 | P |
| Univariate | ||||||||
| Ki67 | 5.6 | 0.018 | 1.6 | 0.201 | 0.8 | 0.371 | 0.2 | 0.608 |
| IHC | 6.2 | 0.104 | 3.8 | 0.148 | 0.1 | 0.934 | 0.2 | 0.588 |
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| LR-Δχ2 | P | LR-Δχ2 | P | LR-Δχ2 | P | LR-Δχ2 | P | |
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| G.Sigs addition to Ki67/IHC | ||||||||
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| Ki67 + G.Sigs | ||||||||
| Ki67 + GGI | 5.2 | 0.022 | 0.8 | 0.378 | 1.1 | 0.289 | 5.8 | 0.015 |
| Ki67 + 70-Gene | 3.5 | 0.060 | 0.1 | 0.771 | 4.6 | 0.031 | 1.2 | 0.271 |
| Ki67 + RS | 6.1 | 0.047 | 3.5 | 0.178 | 1.8 | 0.403 | 0.5 | 0.481 |
| Ki67 + CCS | 7.0 | 0.030 | 0.9 | 0.629 | 5.7 | 0.056 | 5.5 | 0.064 |
| Ki67 + PAM50 | 9.6 | 0.048 | 6.2 | 0.181 | 7.0 | 0.137 | 0.5 | 0.775 |
| IHC + G.Sigs | ||||||||
| IHC + GGI | 5.6 | 0.017 | 0.5 | 0.467 | 2.7 | 0.102 | 5.9 | 0.015 |
| IHC + 70-Gene | 4.4 | 0.035 | 0.1 | 0.789 | 6.8 | 0.009 | 1.4 | 0.230 |
| IHC + RS | 7.2 | 0.026 | 3.2 | 0.200 | 3.2 | 0.201 | 0.8 | 0.375 |
| IHC + CCS | 7.5 | 0.023 | 1.1 | 0.576 | 9.3 | 0.009 | 5.5 | 0.064 |
| IHC + PAM50 | 13.1 | 0.010 | 8.1 | 0.088 | 8.3 | 0.081 | 0.9 | 0.630 |
| Ki67/IHC addition to G.Sigs | ||||||||
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| G.Sigs + Ki67 | ||||||||
| GGI + Ki67 | 0.3 | 0.591 | 0.3 | 0.612 | 0 | 0.957 | 0 | 0.975 |
| 70-Gene + Ki67 | 0.5 | 0.480 | 1.5 | 0.225 | 0.4 | 0.547 | 0 | 0.892 |
| RS + Ki67 | 1.0 | 0.327 | 0.5 | 0.478 | 0.1 | 0.790 | 0.1 | <0.001 |
| CCS + Ki67 | 0.2 | 0.620 | 0.6 | 0.437 | 0.5 | 0.466 | 0.1 | 0.755 |
| PAM50 + Ki67 | 0.4 | 0.553 | 0 | 0.919 | 0 | 0.875 | 0.1 | 0.741 |
| G.Sigs + IHC | ||||||||
| GGI + IHC | 1.3 | 0.726 | 2.2 | 0.332 | 0.9 | 0.642 | 0.1 | 0.796 |
| 70-Gene + IHC | 2.0 | 0.577 | 3.6 | 0.161 | 1.9 | 0.391 | 0.3 | 0.600 |
| RS + IHC | 2.7 | 0.443 | 2.5 | 0.291 | 0.8 | 0.671 | 0.4 | <0.001 |
| CCS + IHC | 1.4 | 0.704 | 3.0 | 0.226 | 3.4 | 0.180 | 0.1 | 0.723 |
| PAM50 + IHC | 4.4 | 0.218 | 4.0 | 0.133 | 0.7 | 0.719 | 0.6 | 0.457 |
Abbreviations: LR-χ2, likelihood ratio; LN, lymph node metastasis; IHC, immunohistochemical markers; events, number of deaths from breast cancer.