Table 2.
Presence of Human G3PDH DNA in Sprague–Dawley Rats
| Organs/Tissues | Presence of Human DNA | ||
|---|---|---|---|
|
| |||
| 24 Hours | 7 Days | 30 Days | |
| Blood | − | − | − |
| Bone marrow | − | − | + |
| Brain | + | + | + |
| Spinal cord | + | + | + |
| Spleen | + | + | − |
| Kidney | + | + | + |
| Liver | + | + | + |
| Heart | + | − | − |
| Lung | − | − | − |
| Gonad | − | + | + |
Nontransgenic Sprague–Dawley rats were given a single injection of 2.2 × 106 HUCBCs via the tail vein. Twenty-four hours after injection, human DNA was detectable in the brain, spinal cord, spleen, kidney, liver, and heart, but not in blood, bone marrow, lung, or gonad. By 30 days, human DNA was found in the bone marrow, brain, spinal cord, kidney, liver, and gonad, while the blood, spleen, heart, and lung were negative (n = 6 per group).