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. Author manuscript; available in PMC: 2019 Feb 15.
Published in final edited form as: J Immunol. 2018 Jan 8;200(4):1496–1503. doi: 10.4049/jimmunol.1701061

Figure 4.

Figure 4

(A) The genetic variant rs76546355 (rs116799036) which explains the most robust genetic association for Behçet’s disease and previously thought to be in a non-transcribed genetic region is expressed within four lincRNA transcripts between HLA-B and MICA. (B) RNA sequencing revealed that these lincRNA transcripts are exclusively expressed from the DNA strand with the disease protective allele (allele G), and no expression was detected from the disease risk allele (allele A). RT PCR followed by Sanger sequencing confirmed expression of the novel lincRNA transcripts in this locus, and allele expression imbalance in rs76546355 (a representative chromatogram of seven heterozygous samples is shown) (C).