Table 2.
Kinetic modeling of drug release data
| Release medium | Correlation coefficient (r2)
|
Release order | Korsmeyer–Peppas
|
Main transport mechanism | |||
|---|---|---|---|---|---|---|---|
| Zero order | First order | Higuchi model | r2 | Diffusional exponent (n) | |||
| SGF/SIF Burst release phase |
0.990 | 0.990 | 0.992 | Higuchi | 0.998 | 0.702 | Non-Fickian |
| SGF/SIF Gradual release phase |
0.994 | 0.970 | 0.999 | Higuchi | 0.988 | 0.132 | Fickian |
| PBS (pH 7.4) Burst release phase |
0.977 | 0.994 | 0.997 | Higuchi | 0.998 | 0.647 | Non-Fickian |
| PBS (pH 7.4) Gradual release phase |
0.975 | 0.992 | 0.999 | Higuchi | 0.999 | 0.137 | Fickian |
Abbreviations: SGF, simulated gastric fluid; SIF, simulated intestinal fluid; PBS, phosphate-buffered saline.