Table 4.
Parameters of macroscopical evaluation of ethanol-induced ulcers in rats
| Animal group | Number of ulcers Mean ± SE n=6 |
Percentage incidence of animals | Paul’s index | AA | Severity of inflammation |
|---|---|---|---|---|---|
| I (normal control) | – | 0 | 0 | – | − (no inflammation) |
| II (positive control) | 26.50±2.32 | 100 | 26.50 | – | +++ (severe) |
| III (100 mg/kg free naringin) | 18.00±1.81# | 83.33 | 14.99 | 1.77 | ++ (moderate) |
| IV (200 mg/kg free naringin) | 7.50±1.04###,$$ | 66.67 | 5.00 | 5.30 | + (mild) |
| V (100 mg/kg naringin–PF68 micelles) | 8.75±0.85###,$ | 66.67 | 5.83 | 4.55 | + (mild) |
Notes:
#
P<0.05 and
###
P<0.001 vs positive control group (II).
$
P<0.05 and
$$
P<0.01 vs 100 mg/kg free naringin pretreated group (III).
Abbreviations: AA, antiulcer activity; SE, standard error; PF68, pluronic F68.