Table 6.

Effects of micelled naringin (100 mg/kg) on tumor growth in mice-bearing EAC cells in comparison with cisplatin (1 mg/kg) and free naringin (100 mg/kg)

Treatment group	Tumor size (mm3)
	Day 0	Day 14	ΔT/ΔC (%)	Percentage of inhibition
EAC-bearing mice	72.40±4.27	722.4±41.91	100	0
Cisplatin	71.33±3.97	206.2±12.70‡	20	80
Naringin	70.00±3.86	346.0±19.26‡,*	42	58
Naringin–PF68 micelles	74.33±4.44	258.0±13.35‡,@	28	72

Notes: Data are expressed as mean ± SE (n=6). ΔT, changes of tumor size in the treatment group; ΔC, changes of tumor size in the EAC-bearing mice; ΔT/ΔC (%), percentage of tumor growth.

^‡P<0.05 vs EAC-bearing mice group,

^@P<0.05 vs free naringin group,

^*P<0.05 vs cisplatin group.

Abbreviations: EAC, Ehrlich ascites carcinoma; PF68, pluronic F68.