Skip to main content
. Author manuscript; available in PMC: 2018 Feb 22.
Published in final edited form as: Nat Rev Cancer. 2017 Mar 3;17(4):239–253. doi: 10.1038/nrc.2017.5

Figure 2. Somatic mutation frequencies (single-nucleotides, small insertions or deletions (indels)) in common cancers from the Catalogue of Somatic Mutations in Cancer (COSMIC).

Figure 2

The top 9 mutations occurring in the different depicted common tumour-types are shown. Mutations shared across tumour entities are depicted by coloured boxes. Mutation data were obtained from the COSMIC release version 77 at Welcome Trust Sanger Institute (http://cancer.sanger.ac.uk/cosmic). Please note: only the frequency of somatic mutations (single-nucleotides or indels), but not larger deletions, amplifications or rearrangements are depicted in the figure. NSCLC, non-small cell lung cancer; PDAC, pancreatic ductal adenocarcinoma; T-ALL, T-cell acute lymphoblastic leukaemia. APC, adenomatous polyposis coli, ARID1A, AT-rich interactive domain 1A, ATM, ataxia telangiectasia mutated; ATR, ataxia telangiectasia and Rad3-related; BAP1, BRCA1-associated protein 1; CDH1, cadherin 1; CDKN2A, cyclin-dependent kinase inhibitor 2A; CREBBP, CREB-binding protein; CTNNB1, encoding β-catenin; DMN2, dynamin 2; EGFR, epidermal growth factor receptor; ESR1, oestrogen receptor 1; EZH2, enhancer of zeste homologue 2; FAT, atypical cadherin; FBXW7, F-box and WD repeat domain containing 7; GATA3, GATA binding protein 3; GNAS, encoding G protein, GαS; GRIN2A, glutamate receptor ionotropic, NMDA 2A; JAK3, Janus kinase 3; KDM5C, lysine-specific demethylase 5C; KMT2, histone-lysine N-methyltransferase 2; NCOR1, nuclear receptor co-repressor 1; MYD88, myeloid differentiation primary response 88; NF1, neurofibromatosis type 1; PBRM1, polybromo 1; SETD2, SET domain containing 2; PHF6, PHD finger protein 6; SMARCA4, SWI/SNF related, matrix associated, actin-dependent regulator of chromatin, subfamily A, member 4; SOCS1, suppressor of cytokine signalling 1; SPOP, speckle-type POZ protein; STK11, serine-threonine kinase 11; TERT, telomerase reverse transcriptase; TNFAIP3, tumour necrosis factor α (TNFα)-induced protein 3; TSC2, tuberous sclerosis 2; TRRAP, transformation/transcription domain associated protein; VHL, von Hippel-Lindau tumour suppressor; WT1, Wilms tumour 1.