Appendix Table 6.

Outcomes with FIT screening strategies that vary by the ages to begin and end screening among transplant Cystic Fibrosis patients.

	Outcomes per 1,000 transplant cystic fibrosis individuals free of diagnosed cancer at age 30 years in 2017 (with organ transplant at age 30, 3% discounted)
	Screening tests		Surveillance COLs	Total COLs	Compli -cations	CRC Casesc	CRC deatha,c	LY with CRC	LYGb	Total costs (*$1,000)	Net costs (*$1,000)	Reductionsb (%)		Efficient strategy
	FIT	COLs										CRC incidencec	CRC mortalityc
No screening	0	0	0	30	0	52	22	115	0	2064654	0	0	0	Dominated
FIT 50–55 y	327	0	88	189	1	54	15	153	13	2467521	402866	−3	35	Dominated
FIT 50–60 y	360	0	92	198	1	54	14	155	13	2496400	431746	−4	36	Dominated
FIT 50–65 y	364	0	92	199	1	54	14	156	13	2501575	436920	−4	37	Dominated
FIT 50–70 y	364	0	92	199	1	54	14	156	13	2501575	436920	−4	37	Dominated
FIT 50–75 y	364	0	92	199	1	54	14	156	13	2501575	436920	−4	37	Dominated
FIT 45–55 y	813	0	181	322	1	48	11	165	25	2517648	452994	8	53	Dominated
FIT 45–60 y	840	0	184	329	1	48	10	167	26	2541004	476350	7	54	Dominated
FIT 45–65 y	843	0	184	329	1	49	10	167	26	2545324	480670	7	54	Dominated
FIT 45–70 y	843	0	184	329	1	49	10	167	26	2545324	480670	7	54	Dominated
FIT 45–75 y	843	0	184	329	1	49	10	167	26	2545324	480670	7	54	Dominated
FIT 40–55 y	1722	0	283	466	2	44	8	172	38	2589414	524759	15	65	Dominated
FIT 40–60 y	1745	0	286	472	2	45	8	173	38	2610117	545463	14	66	Dominated
FIT 40–65 y	1748	0	286	473	2	45	8	173	38	2614004	549350	14	66	Dominated
FIT 40–70 y	1748	0	286	473	2	45	8	173	38	2614004	549350	14	66	Dominated
FIT 40–75 y	1748	0	286	473	2	45	8	173	38	2614004	549350	14	66	Dominated
FIT 35–55 y	3419	0	377	620	2	42	6	175	48	2755648	690993	19	72	Efficient
FIT 35–60 y	3440	0	380	625	2	42	6	177	48	2774500	709845	18	73	Dominated
FIT 35–65 y	3443	0	380	626	2	43	6	177	48	2778104	713449	18	73	Dominated
FIT 35–70 y	3443	0	380	626	2	43	6	177	48	2778104	713449	18	73	Dominated
FIT 35–75 y	3443	0	380	626	2	43	6	177	48	2778104	713449	18	73	Dominated
FIT 30–55 y	6702	0	460	811	2	41	5	177	54	3049935	985281	21	76	Efficient
FIT 30–60 y	6722	0	463	816	2	41	5	178	54	3067680	1003026	20	77	Optimal
FIT 30–65 y	6725	0	463	816	2	42	5	178	54	3071052	1006398	20	77	Dominated
FIT 30–70 y	6725	0	463	816	2	42	5	178	54	3071052	1006398	20	77	Dominated
FIT 30–75 y	6725	0	463	816	2	42	5	178	54	3071052	1006398	20	77	Dominated

COL indicates colonoscopy; CRC, colorectal cancer; LY, Life-years; LYG, LY gained compared with no screening; FIT, Fecal immunochemical test; Grey row indicates optimal screening strategy.

^aIncluding deaths from complications of screening;

^bcompared with no screening;

^cCRC cases and CRC death were not discounted.