Appendix Table 2.

Costs associated with colorectal cancer screening in the base case and cost sensitivity analysis.

	Costs, $a	Higher costs for colonoscopy, $ (Sensitivity analysis)e
Per FIT	40	-
Per colonoscopy
Without polypectomy/biopsy	880	1,400
With polypectomy/biopsy	1,200	1,700
Per complication of colonoscopy
Seriousb GI complications	8,100	11,200
Otherc GI complications	6,200	7,600
Cardiovascular complicationsd	6,700	8,500
Per LY with CRC care
Initial care
Stage I CRC	36,900	-
Stage II CRC	49,500	-
Stage III CRC	60,100	-
Stage IV CRC	78,200	-
Continuing care
Stage I CRC	3,100	-
Stage II CRC	2,900	-
Stage III CRC	4,100	-
Stage IV CRC	12,300	-
Terminal Care, ending in CRC death
Stage I CRC	64,200	-
Stage II CRC	63,900	-
Stage III CRC	67,400	-
Stage IV CRC	88,900	-
Terminal Care, ending in other-cause death
Stage I CRC	19,400	-
Stage II CRC	17,400	-
Stage III CRC	21,600	-
Stage IV CRC	50,200	-

GI = Gastro intestinal; FIT = Fecal immunochemical test.

^aCosts are presented in 2015 U.S. dollars and include co-payments and patient time costs (i.e., the opportunity costs of spending time on screening or being treated for a complication or CRC) but do not include travel costs, costs of lost productivity, and unrelated health care and non–health care costs in added years of life. We assumed that the value of patient time was equal to the median wage rate in 2014: $17.01/h. Cost values were estimated for the year 2014. We assumed that FITs, colonoscopies, and complications used up 1, 8, and 16 h of patient time, respectively. Patient time costs were already included in the estimates for the costs of LYs with CRC care obtained from a study by Yabroff et al⁴⁰; All costs were adjusted for the year 2015 using the annual average Consumer Price Indexes provided by US Bureau of Labor Statistics⁴¹;

^bSerious GI complications included perforations, gastrointestinal bleeding, or transfusions;

^cOther GI complications included paralytic ileus, nausea and vomiting, dehydration, or abdominal pain;

^dCardiovascular complications included myocardial infarction or angina, arrhythmias, congestive heart failure, cardiac or respiratory arrest, syncope, hypotension, or shock;

^eWe assumed that colonoscopies, and complications used up 40 and 190 h of patient time, respectively.