Table. Characteristics of Nannizziopsis sp. infection in humans*.
Year (reference) | Age, y/sex | Country | Underlying condition or context | Species | Localization | Positive samples | Treatment | Outcome |
---|---|---|---|---|---|---|---|---|
2017 (this study) |
52/F |
France |
HIV, living in Mali |
Nannizziopsis sp. |
Brain abscess |
Cerebral biopsy, CSF |
AmpB for 1 mo, then VCZ |
Recovery but neurologic sequela after 2 mo |
2015 (this study) |
63/F |
France |
Leukemia, recent travel to Senegal |
N. obscura
|
Brain abscess |
Blood culture, CSF, ascites fluid |
Not treated
(death before diagnosis) |
Death before diagnosis |
2005 (2) |
38/M |
Germany |
HIV, travel to Nigeria |
N. obscura
|
Brain abscess |
Needle aspiration of brain lesion |
VCZ |
Recovery without sequelae after 4 mo |
2005 (5) |
40/M |
United States |
HIV |
N. infrequens
|
Lung |
Bronchial washing |
Not treated,
considered as a contaminant |
Recovery after treatment of CMV infection |
2000 (3,4) |
32/M |
United States |
Travel to Nigeria |
N. hominis
|
Lymph nodes, heart, lungs, spleen, kidneys |
3 lymph nodes |
ITRA for 2 y |
NA |
1994 (3) |
NA/M |
United States |
HIV |
N. hominis
|
Right thigh mass |
Deep muscle mass on the right thigh, right groin, buttock, and lung |
ITRA |
Death after 8 mo |
1982 (1) | 24/M | United States | Travel to Africa | N. obscura | Abscess in right ankle, osteomyelitis | 2 biopsies of abscess in tibia | AmpB for 4 mo | Recovery after 4 mo |
*AmpB, amphotericin B; CMV, cytomegalovirus; CSF, cerebrospinal fluid; ITRA, itraconazole; NA, not available; VCZ, voriconazole.