Table 1. Summary of LF-induced SNHL case studies.
Case No. [Ref.] | Location | Symptoms | Confirmation of LASV | Treatment | Onset of Hearing Loss | Unilateral or Bilateral Hearing Loss | Follow-up of Hearing Loss |
---|---|---|---|---|---|---|---|
1 [28] | Nigeria | Headache, chest pain, diarrhea, vomiting, high fever | LASV detected in serum and serum positive for LASV antibodies | No specific treatment for LF | 13 days after onset of fever | Not reported | Present several months later |
2 [30] | Liberia | Fever, chills, weakness, diarrhea, cough, lower abdominal and lumbosacral pain, pharyngitis, maculopapular rash on face, headache, lymphadenopathy, periorbital edema, conjunctivitis, vomiting | LASV detected in serum and serum positive for LASV antibodies | No specific treatment for LF | 17 days after onset of fever | Unilateral | No follow-up performed |
3 [32] | Sierra Leone | Fever, abdominal pain, chills, headache, myalgia, arthralgia, conjunctival injection, lymphadenopathy | Serum positive for LASV antibodies | No specific treatment for LF | Upon entering convalescence phase | Unilateral | Still present upon discharge |
4 [33] | Nigeria | High fever, vomiting, abdominal pain, diarrhea, sore throat, difficulty swallowing | rt-PCR | 10-day ribavirin | While taking ribavirin | Unilateral | Still present after 4 years; uses hearing aid |
5 [33] | Nigeria | High fever | rt-PCR | 10-day ribavirin | 8 days after onset of fever | Bilateral | Still present after 1 year |
6 [34] | Liberia | Fever, nausea, arthralgia, headache, diarrhea, personality changes, encephalitis | LASV detected in serum and CSF | No specific treatment for LF | 22 days after onset of symptoms | Bilateral | Still present 2 months later |
Abbreviations: CSF, cerebral spinal fluid; LASV, Lassa virus; LF, Lassa fever; rt-PCR, reverse transcriptase polymerase chain reaction; SNHL, sensorineural hearing loss.