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. 2018 Feb 22;12(2):e0006187. doi: 10.1371/journal.pntd.0006187

Table 1. Summary of LF-induced SNHL case studies.

Case No. [Ref.] Location Symptoms Confirmation of LASV Treatment Onset of Hearing Loss Unilateral or Bilateral Hearing Loss Follow-up of Hearing Loss
1 [28] Nigeria Headache, chest pain, diarrhea, vomiting, high fever LASV detected in serum and serum positive for LASV antibodies No specific treatment for LF 13 days after onset of fever Not reported Present several months later
2 [30] Liberia Fever, chills, weakness, diarrhea, cough, lower abdominal and lumbosacral pain, pharyngitis, maculopapular rash on face, headache, lymphadenopathy, periorbital edema, conjunctivitis, vomiting LASV detected in serum and serum positive for LASV antibodies No specific treatment for LF 17 days after onset of fever Unilateral No follow-up performed
3 [32] Sierra Leone Fever, abdominal pain, chills, headache, myalgia, arthralgia, conjunctival injection, lymphadenopathy Serum positive for LASV antibodies No specific treatment for LF Upon entering convalescence phase Unilateral Still present upon discharge
4 [33] Nigeria High fever, vomiting, abdominal pain, diarrhea, sore throat, difficulty swallowing rt-PCR 10-day ribavirin While taking ribavirin Unilateral Still present after 4 years; uses hearing aid
5 [33] Nigeria High fever rt-PCR 10-day ribavirin 8 days after onset of fever Bilateral Still present after 1 year
6 [34] Liberia Fever, nausea, arthralgia, headache, diarrhea, personality changes, encephalitis LASV detected in serum and CSF No specific treatment for LF 22 days after onset of symptoms Bilateral Still present 2 months later

Abbreviations: CSF, cerebral spinal fluid; LASV, Lassa virus; LF, Lassa fever; rt-PCR, reverse transcriptase polymerase chain reaction; SNHL, sensorineural hearing loss.