Table 4. Correlation between DNA methylation, RNA-Seq, and protein levels.
| DNA Methylation | RNA-Seq | Protein Levels | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene | CpG | dm | CpG location | p | Fold Change | p | Fold Change | p | Gene Function | |
| All Pairs | PIWIL3 | cg24436207 | 0.11 | promoter, weak enhancer | 9.8E-04 | -1.43 | 0.403 | -1.45 | 0.013 | PIWI Argonaute protein; RNA silencing |
| cg03438754 | 0.12 | 3.7E-04 | ||||||||
| Male Pairs | CYBA | cg26537639 | -0.13 | active promoter & CpG island | 2.4E-04 | 1.96 | 0.253 | 1.45 | 0.043 | Component of NADPH oxidase complex |
| cg04879832 | -0.15 | 2.1E-04 | ||||||||
| GSTM1 | cg10950028 | -0.23 | promoter w/ CpG island | 3.5E-04 | 6.49 | 0.389 | 2.68 | 0.027 | Members of GST protein family that neutralize ROS and toxins to prevent DNA damage | |
| GSTM5 | cg12858902 | -0.27 | promoter | 2.7E-04 | 1.53 | 0.421 | 3.86 | 0.042 | ||
| cg05376982 | -0.15 | 6.3E-04 | ||||||||
| cg25593510 | -0.28 | 9.1E-04 | ||||||||
| cg23719124 | -0.09 | 2.0E-04 | ||||||||
| Female Pairs | KCNE1 | cg23480619 | 0.20 | CpG island and poised promoter | 1.2E-04 | -2.15 | 0.528 | -1.96 | 0.051 | Potassium channel whose currents are suppressed by insulin |
| cg08823027 | 0.09 | 8.4E-04 | ||||||||
| cg23908228 | 0.11 | 2.3E-04 | ||||||||
| cg07321776 | 0.13 | 1.3E-05 | ||||||||
| cg19521832 | 0.15 | 7.5E-04 | ||||||||
| cg14535332 | 0.20 | 2.8E-05 | ||||||||
| NXN | cg08192143 | 0.05 | weak enhancer | 3.0E-04 | -1.86 | 0.060 | -2.08 | 0.019 | Redox-dependent regulator of Wnt signaling pathway; involved in cell growth and differentiation | |
| cg19431200 | 0.05 | 6.4E-04 | ||||||||
| cg20403644 | 0.06 | 5.7E-04 | ||||||||
| cg15019011 | 0.08 | 4.9E-04 | ||||||||
| cg24015037 | 0.10 | 4.3E-04 | ||||||||