Table 2. Static compliance before and after sevoflurane application.
| 6h KET | 5h KET +1h SEV |
3h KET +3h SEV |
1h KET +5h SEV |
6h SEV | P | |
|---|---|---|---|---|---|---|
| 6h average | ||||||
| mCstat [μl/cmH2O] | 39 (± 3) |
40 (± 2) |
41 (± 4) |
38 (± 3) |
37 (± 5) |
ns |
| before SEV application | ||||||
| mCstat [μl/cmH2O] | 39 (± 3) |
41 (± 2) |
42 (± 3) |
39 (± 2) |
ns | |
| during SEV application | ||||||
| mCstat [μl/cmH2O] | 36 (± 2) |
40 (± 4) |
38 (± 3) |
37 (± 5) |
ns | |
| P (before vs after) | < 0,0001 | ns | ns | |||
Mice were mechanically ventilated with 12 ml/kg for 6 h either under ketamine + acepromazine (6h KET) or sevoflurane (6h SEV) anesthesia or a combination of both: KET for 5, 3, or 1 h, followed by SEV for another 1, 3, or 5 h as indicated (5h KET + 1h SEV, 3h KET + 3h SEV, 1h KET + 5h SEV). Mean static compliance (mCstat) was monitored throughout ventilation and depicted as mean before and during SEV application. Data represent means ± SD for n = 6 (3h KET + 3h SEV; 6h SEV) or n = 7/group. ANOVA (Tukey`s post hoc test) for comparisons between all groups, t-Test for intergroup comparisons (before and after SEV treatment).