Fig 1. The smallest revertant patch observed in any of our patients.

Photograph of the revertant patch on the dorsal middle finger of patient EB093-01 (deceased) who had generalized intermediate junctional EB due to compound heterozygous COL17A1 mutations c.[3676C>T];[4319dup], p.[Arg1226*];[Gly1441Trpfs*14] [9]. Note stitched biopsy site for confirmation of type XVII collagen re-expression. The size of the patch was approximately 2 cm² and it allowed him to wear a wedding ring. Based on this, we concluded revertant patches should be ~1 cm² minimum in order to be clinically recognizable.