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. 2018 Feb 22;13(2):e0192994. doi: 10.1371/journal.pone.0192994

Fig 3. A selective growth advantage of revertant cells is supported by the patterns of the revertant skin patches.

Fig 3

(A) Dorsal forearm of an 8-year old boy (EB134-01) with generalized intermediate junctional EB due to the compound heterozygous COL17A1 mutations c.[1260del];[3496_3497del], p.[Thr421Leufs*72];[Ser1166Leufs*6] showing a revertant patch (indicated by blue line). (B) The lines of Blaschko on the dorsal forearm as deduced by Blaschko and Happle [49,50]. (C) The lines of Blaschko projected on the revertant patch on the dorsal forearm of patient EB134-01. The revertant patch has clearly exceeded the boundaries of the Blaschko lines and has grown into adjacent Blaschko line segments. The parents of patient EB134-01 have given written informed consent (as outlined in PLOS consent form) to publish this photograph.