Fig 7. Whole blood levels of C16 after 7-day continuous PO dosing via medicated gels and comparison with projected C16 EC₅₀ value (10 nM or 6.32 ng/mL).

N = 4, except for the 300 mg/kg evening condition (N = 3). Respectively 2 and 3 animals had C16 levels below the limit of quantification in the 0 mg/kg evening and morning conditions. Statistics: ANOVA or Mann-Whitney U test.