Table 1. Solubility of C16 in vehicles suitable for in vivo evaluation.

		Concentration (mg/mL)	Result
a	DMSO	10	Soluble a
b	10% DMSO in normal saline	1	Insoluble a
c	50% DMSO in normal saline	1	Insoluble a
d	10% (DMSO / Cremophor EL 1:1) / 90% Milli-Q water	2	Insoluble a
e	20% DMSO / 10% (DMSO / Cremophor EL 1:1) / 70% Milli-Q water	2	Soluble a
f	10% Cremophor EL / 10% EtOH	10	Insoluble b
g		30	Insoluble b
h	10% DMA / 10% EtOH / 20% PG	10	Insoluble b
i		30	Insoluble b
j	10%DMA / 20%PG / 40% PEG 400	10	Insoluble b
k		30	Insoluble b
l	40% PEG 400 / 10% EtOH	10	Insoluble b
m		30	Insoluble b
n	20% PEG 400 / 10% Cremophor EL	10	Insoluble b
o		30	Insoluble b
p	10% Solutol HS-15 / 90% PEG 600	10	Soluble b
q		30	Soluble b
r	100% Corn oil	10	Insoluble b
s		30	Insoluble b
t	10% Dimethylacetamide (DMA) / 90% PEG 600	10	Soluble b
u		30	Soluble b

^a Visual determination.

^b Laser nephelometry.