Table 7. Clinical chemistry and hematology results after 7-day continuous PO dosing via medicated gels versus the water control group(average±SD).
| Parameter | Cohort | |||
|---|---|---|---|---|
| 0 mg/kg | 100 mg/kg | 300 mg/kg | water | |
| Clinical chemistry | ||||
| ALP (IU/L) | 92±12 | 118±33 | 94±18 | 93±14 |
| ALT (IU/L) | 43±19 | 70±40 | 43±9 | 78±36 |
| AST (IU/L) | 188±84 | 345±365 | 221±65 | 466±387 |
| CHO (mg/dL) | 91±17 | 96±21 | 73±18 | 91±8 |
| GLUC (mg/dL) *,a | 206±11 a | 218±30 * | 206±24 a | 136±57 |
| TP (g/L) | 37.8±1.0 | 42.0±4.5 | 31.6±21.3 | 45.7±3.6 |
| TRIGL (mg/dL) | 207±79 | 110±45 | 123±55 | 108±21 |
| Hematology | ||||
| WBC (103/μL) | 3.02±0.77 | 3.05±0.08 | 2.97±0.94 | 1.62 |
| RBC (106/μL) | 7.02±1.40 | 8.32±0.69 | 6.32±1.92 | 8.09 |
| HGB (g/dL) | 11.3±2.0 | 12.2±0.2 | 10.1±2.9 | 13 |
| HCT (%) | 37.7±7.1 | 44.5±5.2 | 34.0±7.78 | 40.9 |
| MCV (fL) | 53.8±0.6 | 53.4±1.8 | 54.5±4.24 | 50.6 |
| MCH (pg) | 16.2±0.4 | 14.7±1.5 | 16.0±0.2 | 16.1 |
| PLT (103/μL) | 258±41 | 281±33 | 2665±12 | 338 |
| NEUT (%) | 28.6±4.7 | 16.9±4.9 | 39.9 | 43.2 |
| LYMP (%) | 65.4±9.9 | 79.2±3.4 | 60.1 | 56.8 |
| MONO (%) | 1.4±1.3 | 2.5±0.6 | 2.6±3.7 | 0 |
| EO (%) | 0.4±0.5 | 0±0 | 0±0 | 0 |
| BASO (%) | 0.08±0.2 | 0.2±0.2 | 0±0 | 0 |
| NRBC (103/μL) | 0±0 | 0.75±1.06 | 0.35±0.49 | 1.2 |
| IG (103/μL) | 0±0 | 0.04±0.06 | 0 | 0 |
Abbreviations: WBC: white blood cells; RBC: red blood cells; HGB: hemoglobin; HCT: hematocrit; MCV: Mean corpuscular volume; MCH: Mean corpuscular hemoglobin; PLT: platelets; PCT: platelet hematorcrit; ALP: alkaline phosphatase; ALT: alanine transaminase; AST: aspartate transaminase; CHO: cholesterol;; GLUC: glucose; IG: immature granulocytes; NRBC: nucleated red blood cells; TP: total protein; TRIGL: triglicerides;
* Significant difference in glucose level between 100 mg/kg and water cohort (p = 0.028);
a Marginally significant difference between 0 mg/kg and blank cohort (p = 0.062), and between 300 mg/kg and blank cohort (p = 0.063).