Fig 1. Sampling scheme for simulated single-lab and multi-lab studies.

For a single-lab study, 1 original study is randomly selected from the study pool, and response values for control and treatment groups are generated by sampling from a Normal distribution with parameters as reported in the original study. For the multi-lab study, several original studies are selected, and values are sampled proportionate from the corresponding distributions. C, control group; SP, study pool; T, treatment group.