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. 2018 Feb 9;12(2):e0006209. doi: 10.1371/journal.pntd.0006209

Fig 3. Identification of VIS513 escape mutants.

Fig 3

A. Neutralization profile of a titration of 14c10 with DENV1 population passaged in presence of 14c10 at 100 μg/ml, 10 μg/ml, or trastuzumab at 150 μg/ml for 5 passages. B-C. Neutralization profile of a titration of VIS513 with DENV3 (passage 7) (B) or DENV4 (passage 5) (C) passaged in the presence of indicated concentrations of VIS513 or trastuzumab. For DENV4, passaging in the presence of 150 μg/ml VIS513 yielded insufficient virus for subsequent neutralization assays and hence could not be assayed. The solid lines and error bars represent mean ± SEM of experiment performed in triplicate.