Table 2. Summary of escape mutations observed from cell culture studies.

Serotype	mAb	Mutations (E gene)	Binding Affinity (nM)
DENV1 HAW	14c10	K136E K204R	ND ND
	VIS513	K310R WT	0.39 <0.1
DENV2 NGC	VIS513	K310R WT	0.79 <0.1
DENV3 H87	VIS513	L301S K308R WT	1.7 169.8 1.5
DENV4 BC287	VIS513	K310R WT	617.6 6.1

ND = not determined