Fig 7. Model for aminomethylphenoxy benzoxaboroles metabolism in vivo.

In the host, the aminomethylphenoxy benzoxaboroles are first oxidized by SSAO in the intravascular system. The resulting aldehyde metabolites are taken up by the parasites, and further oxidized into carboxylic acids that give rise to the final active trypanocides. The activation of the compounds requires both enzymatic activities in the host and parasites, with the loss of drug potency when either enzymatic activity is compromised. The key chemical moieties undergoing biochemical transitions through this process are highlighted with dotted boxes.