Fig 2. Hematopoietic deficiency of HIC1 results in susceptibility to Citrobacter rodentium infection.
Hic1Vav and Hic1fl/fl mice were orally inoculated with C. rodentium. (A) Weight loss (percentage of initial weight) was calculated for each mouse over course of infection. (B, C) Bacterial loads (CFU/g) from fecal pellets (B) and liver (C) were measured at 11 days post inoculation. (D) Quantitative RT-PCR was performed to determine expression of Il17a, Il22 and Reg3g from distal colon tissue 11 days post inoculation. Data are pooled from 2 independent experiments (n = 8–9 per group). *, P < 0.05; **, P < 0.01; Mann-Whitney test. Error bars indicate SEM. nd, none detected.