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. Author manuscript; available in PMC: 2019 Jan 22.
Published in final edited form as: Phys Med Biol. 2018 Jan 22;63(3):035002. doi: 10.1088/1361-6560/aaa30d

Figure 3.

Figure 3

Delivery efficiency of 40-kDa dextran using fluorescence microscopy after BBB opening. Fluorescence images of sonicated vs. non-sonicated hippocampi (insets) using (A) OFP droplets at 300 kPa, (B) OFP droplets at 450 kPa, (C) DFB droplets at 900 kPa. (D) The average enhanced area due to successful delivery (normalized to the entire hippocampus) and (E) average fluorescence intensity increase for all cohorts, with a dash line representing the threshold of successful delivery defined by the sham group (mean plus 2 time of the standard deviation). Successful delivery was found to be at and above 300 kPa for OFP droplets, and 900 kPa for DFB droplets. Note that OFP represents OFP droplets and DFB for DFB droplets. The scale bar in (A) represents 1 mm.