Table 1. Mutations detected in candidate genes (BRAF, NRAS, and CDKN2A) among melanoma cell lines derived from primary and metastatic melanomas.
| Cell line origin | BRAF | NRAS | CDKN2A |
|---|---|---|---|
| Primary melanoma | |||
| GR-Mel | |||
| LCP-Mel | V600R | del ex 2 | |
| MNG-Mel | |||
| PNP-Mel | V600E | G101W | |
| SBCL2 | Q61L | del ex 1, 2, 3 | |
| ST-Mel | G466E | ||
| UACC 62 | V600E | ||
| WM-115-4 | V600D | ||
| Cutaneous melanoma metastasis | |||
| 397-Mel | del ex 2 | ||
| LB-24-Mel | |||
| M14 | V600E | 455insCdel26 IVS1+2T>C | |
| PR-Mel | V600R | ||
| SN-Mel | V600E | ||
| WM-266-4 | V600D | del ex 1 | |
| PE-MEL-41 | V600E | W110* A148T | |
| PE-MEL-43 | V600E | W110* A148T | |
| PE-MEL-47 | V600E | W110* A148T | |
| Lymph node melanoma metastasis | |||
| 13443-Mel | |||
| CN-Mel | Q61R | ||
| CR-Mel | Q61K | del ex 2 | |
| GL-Mel | del ex 2 | ||
| LCM-Mel | V600R | del ex 1, 2 | |
| MAR-Mel | |||
| SK-Mel-28 | V600E | ||
| COPA 159 | V600E | del ex 1,2,3 | |
| A375 | V600E | E61*; E69* | |
| PNM-Mel | V600E | G101W | |
| Mel 3.0 | Q61L | del ex 1, 2, 3 | |
| INT 9009 | V600E | del ex 1, 2, 3 | |
| MALME 37 | V600E | del ex 1, 2, 3 | |
| ME 33797 | V600E | ||
| UACC 257 | del ex 1, 2, 3 | ||
Abbreviations: del, deletion; ex, exon.