Table 1. Genomic alterations in murine tumors.
| Array CGH | Somatic exome sequencing | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Sample id | Mouse id | Model | Age of tumor onset | Status | Whole chromosome alterations | Segmental alterations | Number of focal alterations- | number of mutations | number of consequence mutations |
| 4 | 4 | ALK | 136 | whole chromosome | 9 (+3;-4;-5;-6;-8;-9;+13;-15;-X) | - | - | 0 | 0 |
| 3 | 3 | ALK | 148 | segmental | 4 (+3;+7;+10;-X) | 1 (+11q) | 1 | 4 | 3 |
| 1 | 1 | ALK | 130 | segmental | 2 (+12;-X) | 1 (+11q) | 3 | 11 | 3 |
| 5 | 5 | ALK | 130 | segmental | 11 (+3;-4;-5;-8;-9;-13;-14;-15;-18;-19;-X) | 1 (-12q) | - | 4 | 1 |
| 2 | 2 | ALK | 197 | focal | 2 (+3;+12) | - | 2 (including MYCN) | - | - |
| 11 | 7 | LSL-Lin28b | 56 | whole chromosome | 1 (+3) | - | - | 0 | 0 |
| 10 | 7 | LSL-Lin28b | 56 | whole chromosome | 3 (+3;+7;+10) | - | - | 0 | 0 |
| 9 | 7 | LSL-Lin28b | 56 | whole chromosome | 1 (+3) | 1 (+11q) | - | 0 | 0 |
| 8 | 6 | LSL-Lin28b | 56 | segmental | 1 (+3) | 1 (-14q) | - | 1 | 1 |
| 7 | 6 | LSL-Lin28b | 56 | segmental | 1 (+3) | 1 (-14q) | - | 1 | 1 |
| 6 | 6 | LSL-Lin28b | 56 | segmental | 1 (+3) | 1 (+11q) | - | 0 | 0 |
| 12 | 8 | LSL-NMYC | 89 | segmental | 1 (+3) | 1 (+16p) | 1 | 0 | 0 |
| 13 | 9 | LSL-NMYC | 46 | focal | - | - | 6 ( all on chromosome 7) | 0 | 0 |
| 14 | 9 | LSL-NMYC | 46 | focal | - | - | 5 (4 on chromosome 7) | 24 | 10 |
| 15 | 10 | LSL-NMYC | 100 | whole chromosome | 2 (+3;+6) | - | 1 | 0 | 0 |
| 16 | 10 | LSL-NMYC | 100 | whole chromosome | 2 (+3;+6) | - | 1 | 1 | 0 |
| 18 | 12 | LSL-NMYC | 88 | whole chromosome | 3 (+3;+6;+12) | - | - | 8 | 1 |
| 17 | 11 | LSL-NMYC | 88 | segmental | 1 (+3) | 1 (+11q) | 2 | 0 | 0 |
| 24 | 18 | TH-MYCN | 86 | flat | - | - | 0 (skint gene locus) | 6 | 3 |
| 20 | 14 | TH-MYCN | 129 | whole chromosome | 1 (+3) | - | 0 (skint gene locus) | 16 | 6 |
| 23 | 17 | TH-MYCN | 65 | flat | - | - | 0 (skint gene locus) | 6 | 2 |
| 19 | 13 | TH-MYCN | 123 | whole chromosome | 1 (+3) | - | 0 (skint gene locus) | 0 | 0 |
| 25 | 19 | TH-MYCN | 82 | flat | - | - | 0 (skint gene locus) | 3 | 0 |
| 21 | 15 | TH-MYCN | 67 | flat | - | - | 0 (skint gene locus) | 0 | 0 |
| 22 | 16 | TH-MYCN | 95 | whole chromosome | 2 (+3;-14) | - | 2 (+ skint gene locus) | 0 | 0 |
| 27 | 21 | TH-MYCN | 80 | focal | - | - | 0 (skint gene locus) | 1 | 1 |
| 26 | 20 | TH-MYCN | 126 | focal | 1 (+3) | - | 3 (+ skint gene locus) | 3 | 1 |
| 28 | 22 | TH-MYCN-ALK | 25 | focal | - | - | 5 | 3 | 1 |
| 29 | 23 | TH-MYCN-ALK | 41 | flat | - | - | - | 0 | 0 |
| 32 | 26 | TH-MYCN-ALK | 29 | flat | - | - | - | 0 | 0 |
| 31 | 25 | TH-MYCN-ALK | 29 | flat | - | - | - | 3 | 1 |
| 33 | 27 | TH-MYCN-ALK | 22 | flat | - | - | - | 0 | 0 |
| 34 | 28 | TH-MYCN-ALK | 22 | flat | - | - | - | 0 | 0 |
| 35 | 29 | TH-MYCN-ALK | 33 | whole chromosome | 1 (+10) | - | - | 0 | 0 |
| 36 | 30 | TH-MYCN-ALK | 33 | flat | - | - | - | 0 | 0 |
| 30 | 24 | TH-MYCN-ALK | 32 | flat | - | - | - | 0 | 0 |
The genomic alterations found in the murine tumors divided up into array CGH and exome sequencing results. Array CGH profiles where evaluated as having whole chromosomal copy number changes, segmental (large chromosomal sections) or focal alterations. For the chromosomal and segmental alterations, we indicate the chromosome or region altered, a + means a gain while a – indicates a loss of chromosomal material. For the focal alterations, we list the number of alterations found. In the exome sequencing columns, we list the total number of mutations and the number of mutations predicted to have a consequence at the protein level.