C: overlapping mutated genes.

Murine gene name	Ensembl murine gene ID	Relation	Human gene name	Ensembl Human gene id	Consequence in murine model
Dicer1	ENSMUSG00000041415	ortholog_one2one	DICER1	ENSG00000100697	missense
Zfp574	ENSMUSG00000045252	ortholog_one2one	ZNF574	ENSG00000105732	missense
Ptch1	ENSMUSG00000021466	ortholog_one2one	PTCH1	ENSG00000185920	missense

We explored enrichment of the mutations found in murine tumors for genes known to be mutated in human neuroblastoma. From Table 2A we can see the number of overlapping genes (3) to not be enriched (0.0865 Fisher’s exact test) for genes mutated in human neuroblastoma 883 for a total of 25 genes showing mutations in the murine tumors. If we restrict this analysis to the MYCN driven tumors we do achieve significance (0.0278 Fisher’s exact test) as 3 out of 16 genes mutated in murine tumors show overlap with the genes mutated in human neuroblastoma. In Table 2B we show the murine and human name and ids for the genes showing mutations in both murine and human tumors.