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. 2017 Dec 14;9(9):8241–8252. doi: 10.18632/oncotarget.23246

Figure 1. HMW-HA promotes proliferation, migration and tube formation of endothelial cells in vitro.

Figure 1

(A) Effect of HMW-HA on the proliferation of endothelial cells. MTT assay shows that HMW-HA at concentrations of 500 and 1000 μg/mL significantly increase the proliferation of endothelial cells after 48 h of cell culture (p < 0.05). (B) Effect of HMW-HA at a concentration of 1000 μg/mL on the migration of endothelial cells: upper panel, PBS-treated group; lower panel, HMW-HA-treated group. (C) HMW-HA significantly improves the migration of endothelial cells after 12 h of cell culture in endothelial cells (p < 0.05). (D) Effect of HMW-HA at a concentration of 1000 μg/mL on endothelial cell tube formation: left panel, PBS-treated group; right panel, HMW-HA-treated group. (E) HMW-HA significantly increases tube formation after 6 h of cell culture in Matrigel (p < 0.01).