Figure 5. PRDX1 promotes osteosarcoma cells growth and metastasis in vivo.

(A) Subcutaneous xenograft model was used to measure the cell growth in vivo. U2-OS^shPRDX1 or U2-OS^Control cells and SAOS-2^PRDX1 or SAOS-2^Vector cells were injected into the flank of nude mice. Resulted showed that knockdown of PRDX1 suppresses tumor growth (top panel) and overexpression of PRDX1 promotes tumor growth in vivo (bottom panel). (B) Representative image of metastatic lesion in lung caused by overexpression of PRDX1. (C) The number of lung metastatic nodules was quantified. Knockdown of PRDX1 dramatically suppresses tumor cells metastasize to lung (left panel). In turn, overexpression of PRDX1 enhances the ability of tumor cells metastasize to lung (Right panel). Magnification of images, × 100.