Table 2. Seven independent SNPs for model development in dataset3.
SNP | CHR | Nearest gene | Region | Location on Chromosomea |
Non-risk | Risk | Risk allele frequency | OR (95%CI)b | P valueb | |
---|---|---|---|---|---|---|---|---|---|---|
Cases | Controls | |||||||||
rs2853677 | 5 | TERT | Intron | 1287194 | T | C | 0.449 | 0.375 | 1.36(1.20-1.55) | 2.70E-06 |
rs2735948 | 5 | TERT | Intergenic | 1299213 | C | T | 0.170 | 0.146 | 1.20(1.01-1.42) | 0.044 |
rs6589664 | 11 | TMEM25 | Exon | 117910014 | G | A | 0.310 | 0.271 | 1.21(1.05-1.39) | 6.80E-03 |
rs494560 | 11 | PHLDB1 | Intron | 118026759 | A | G | 0.801 | 0.746 | 0.73(1.18-1.60) | 4.04E-05 |
rs17748 | 11 | PHLDB1 | UTR-3 | 118033634 | C | T | 0.327 | 0.263 | 1.36(1.18-1.56) | 1.57E-05 |
rs3761121 | 20 | ZGPAT | Intron | 62342695 | A | G | 0.269 | 0.202 | 1.45(1.25-1.69) | 9.85E-07 |
rs1058319 | 20 | SLC2A4RG | UTR-3 | 62374389 | T | C | 0.354 | 0.256 | 1.59(1.39-1.83) | 4.76E-11 |
a, based on NCBI Build 36; b, ORs, 95%CI and P values were calculated from univariate logistic regression analysis based on additive model.