Table 3. Association between the cumulative effect of 5 independent SNPs and glioma risk in dataset2.
| Risk prediction models | Cases (%) | Controls (%) | OR(95%CI) | P value | Trend P value |
|---|---|---|---|---|---|
| 743 | 900 | ||||
| counts Genetic Risk Score (cGRS) | |||||
| 0-1 | 24(3.23) | 54(6.00) | 1.00(reference) | ||
| 2 | 77(10.36) | 142(15.78) | 1.22(0.70-2.13) | 0.482 | |
| 3 | 146(19.65) | 275(30.56) | 1.20(0.71-2.01) | 0.504 | |
| 4 | 220(29.61) | 215(23.89) | 2.30(1.37-3.86) | 0.002 | |
| 5 | 166(22.34) | 135(15.00) | 2.77(1.63-4.71) | 1.76E-04 | |
| ≥6 | 110(14.80) | 79(8.78) | 3.13(1.79-5.49) | 6.62E-05 | 2.73E-12 |
| weighed Genetic Risk Score (wGRS)1 | |||||
| 0(<Q25) | 120(16.15) | 259( 28.78) | 1.00(reference) | ||
| 1(Q25∼Q50) | 107(14.40) | 198(22.00) | 1.17(0.85-1.61) | 0.345 | |
| 2(Q50∼Q75) | 229(30.82) | 219(24.33) | 2.26(1.70-3.00) | 2.14E-08 | |
| 3(≥Q75) | 287(38.63) | 224(24.89) | 2.77(2.10-3.65) | 7.67E-13 | 3.63E-15 |
| weighed Genetic Risk Score (wGRS)2 | |||||
| 0(<Q25) | 120(16.15) | 259(28.78) | 1.00(reference) | ||
| 1(Q25∼Q50) | 107(14.40) | 199(22.11) | 1.16(0.84-1.60) | 0.361 | |
| 2(Q50∼Q75) | 226(30.42) | 219(24.33) | 2.24(1.68-2.98) | 3.12E-08 | |
| 3(≥Q75) | 287(39.03) | 223(24.78) | 2.78(2.10-3.70) | 6.25E-13 | 3.13E-15 |